Research Papers

70.

In Review Allostery Mediates Ligand Binding to WWOX Tumor Suppressor via a Conformational Switch
Schuchardt BJ, Mikles DC, Bhat V, McDonald CB, Sudol M & Farooq A
In Review (2014)
PubMed | PDF

69.

In Review Ligand Binding to WW Tandem Domains of YAP2 Transcriptional Regulator Is Under Negative Cooperativity
Schuchardt BJ, Mikles DC, Hoang LM, Bhat V, McDonald CB, Sudol M & Farooq A
In Review (2014)
PubMed | PDF

68.

In Review Effect of Osmolytes on the Binding of EGR1 TranscriptionFactor to DNA
Mikles DC, Bhat V, Schuchardt BJ, McDonald CB & Farooq A
In Review (2014)
PubMed | PDF

67.

In Review FAM65B Is a Membrane-Associated Protein of Hair Cell Stereocilia Required for Hearing
Diaz-Horta O, Uzak AS, Grati M, DeSmidt A, Foster J, Cao L, Bademci G, Tokgoz-Yilmaz S, Duman D, Cengiz FB, Abad C, Mittal R, Blanton SH, Liu XZ, Farooq A, Walz K, Zhongmin L & Tekin M
PROC NAT ACAD SCI 111, In Press (2014)
PubMed | PDF

66.

In Review A Homozygous SIX6 Mutation is Associated with Optic Disc Anomalies and Macular Atrophy and Reduces Retinal Ganglion Cell Differentiation
Yariz KO, Sakalar YB, Jin X, Hertz J, Emirogullari1 EF, Akay H, Ozbek MN, Farooq A, Goldberg J & Tekin M
CLINICAL GEN 86, In Press (2014)
PubMed | PDF

65.

In Review De Novo ACTG2 Mutations Cause Congenital Distended Bladder, Microcolon and Intestinal Hypoperistalsis
Thorson W, Diaz-Horta O, Foster II J, Spiliopoulos M, Quintero R, Farooq A, Blanton S & Tekin M
HUMAN GEN 133, 737-742 (2014)
PubMed | PDF

64.

In Review Molecular Basis of the Binding of YAP2 Transcriptional Regulator to the ErbB4 Receptor Tyrosine Kinase
Schuchardt BJ, Bhat V, Mikles DC, McDonald CB, Sudol M & Farooq A
BIOCHIMIE 101, 192-202 (2014)
PubMed | PDF

63.

In Review Role of Promoter DNA Sequence Variations on the Binding of EGR1 Transcription Factor
Mikles DC, Schuchardt BJ, Bhat V, McDonald CB & Farooq A
ARCH BIOCHEM BIOPHYS 549, 1-11 (2014)
PubMed | PDF

62.

In Review Molecular Determinants of the Binding Specificity of BH3 Ligands to BclXL Apoptotic Repressor
Bhat V, Olenick MB, Schuchardt BJ, Mikles DC, McDonald CB & Farooq A
BIOPOLYMERS 101, 573-582 (2014)
PubMed | PDF

61.

In Review PNPLA6 Mutations Cause Boucher-Neuhauser and Gordon Holmes Syndrome as Part of a Broad Neurodegenerative Spectrum
Synofzik M, Gonzalez MA, Lourenco CM, Coutelier M, Haack TB, Rebelo A, Hannequin D, Strom TM, Prokisch H, Kernstock C, Durr A, Schols L, Lima-Martinez MM, Farooq A, Schule R, Stevanin G, Marques W & Zuchner S
BRAIN 137, 69-77 (2014)
PubMed | PDF

60.

In Review Enthalpic Factors Override the Polyelectrolyte Effect in the Binding of EGR1 Transcription Factor to DNA
Mikles DC, Bhat V, Schuchardt BJ, McDonald CB & Farooq A
J MOL RECOG 27, 82-91 (2014)
PubMed | PDF

59.

In Review Molecular Origin of the Binding of WWOX Tumor Suppressor to ErbB4 Receptor Tyrosine Kinase
Schuchardt BJ, Bhat V, Mikles DC, McDonald CB, Sudol M & Farooq A
BIOCHEMISTRY 52, 9223-9236 (2013)
PubMed | PDF

58.

In Review Biophysical Basis of the Promiscuous Binding of Bcl2 Apoptotic Repressor to BH3 Ligands
Bhat V, Olenick MB, Schuchardt BJ, Mikles DC, McDonald CB & Farooq A
J MOL RECOG 26, 501-513 (2013)
PubMed | PDF

57.

In Review pH Modulates the Binding of EGR1 Transcription Factor to DNA
Mikles DC, Bhat V, Schuchardt BJ, Deegan BJ, Seldeen KL, McDonald CB & Farooq A
FEBS J 280, 3669-3684 (2013)
PubMed | PDF

56.

In Review Heat-Induced Fibrillation of BclXL Apoptotic Repressor
Bhat V, Olenick MB, Schuchardt BJ, Mikles DC, Deegan BJ, McDonald CB, Seldeen KL, Kurouski D, Faridi MH, Shareef MM, Gupta V, Lednev IK & Farooq A
BIOPHYS CHEM 179, 12-25 (2013)
PubMed | PDF

55.

In Review Dysfunctional Potassium Channel Subunit Interaction as a Novel Mechanism of Long QT Syndrome
Hoosien M, Ahearn ME, Myerburg RJ, Pham TV, Miller TE, Smets MJ, Baumbach-Reardon L, Young ML, Farooq A & Bishopric NH
HEART RHYTHM 10, 728-737 (2013)
PubMed | PDF

54.

In Review Structural Landscape of the Proline-Rich Domain of Sos1 Nucleotide Exchange Factor
McDonald CB, Bhat V, Kurouski D, Mikles DC, Deegan BJ, Seldeen KL, Lednev IK & Farooq A
BIOPHYS CHEM 175, 54-62 (2013)
PubMed | PDF

53.

In Review Allostery Mediates Ligand Binding to Grb2 Adaptor in a Mutually Exclusive Manner
McDonald CB, El Hokayem J, Zafar N, Balke JE, Bhat V, Mikles DC, Deegan BJ, Seldeen KL & Farooq A
J MOL RECOG 26, 92-103 (2013)
PubMed | PDF

52.

In Review Identification, Basic Characterization and Evolutionary Analysis of Differentially Spliced mRNA Isoforms of Human YAP1 Gene
Gaffney CJ, Oka T, Mazack V, Hilman D, Gat U, Muramatsu T, Inazawa J, Golden A, Carey DJ, Farooq A, Tromp G and Sudol M
GENE 509, 215-222 (2012)
PubMed | PDF

51.

In Review Acidic pH Promotes Oligomerization and Membrane Insertion of the BclXL Apoptotic Repressor
Bhat V, Kurouski D, Olenick MB, McDonald CB, Mikles DC, Deegan BJ, Seldeen KL, Lednev IK & Farooq A
ARCH BIOCHEM BIOPHYS 528, 32-44 (2012)
PubMed | PDF

50.

In Review Biophysical Basis of the Binding of WWOX Tumor Suppressor to WBP1 and WBP2 Adaptors
McDonald CB, Buffa L, Bar-Mag T, Salah Z, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Malhotra A, Sudol M, Aqeilan RI, Nawaz Z & Farooq A
J MOL BIOL 422, 58-74 (2012)
PubMed | PDF

49.

In Review Bivalent Binding Drives the Formation of Grb2-Gab1 Signaling Complex in a Non-Cooperative Manner
McDonald CB, Bhat V, Mikles DC, Deegan BJ, Seldeen KL & Farooq A
FEBS J 279, 2156-2173 (2012)
PubMed | PDF

48.

In Review Multivalent Binding and Facilitated Diffusion Account for the Formation of Grb2-Sos1 Signaling Complex in a Cooperative Manner
McDonald CB, Balke JE, Bhat V, Mikles DC, Deegan BJ, Seldeen KL & Farooq A
BIOCHEMISTRY 51, 2122-2135 (2012)
PubMed | PDF

47.

In Review A Novel Nuclear Role for the Vav3 Nucleotide Exchange Factor in Androgen Receptor Coactivation in Prostate Cancer
Rao S, Lyons LS, Fahrenholtz CD, Wu F, Farooq A, Balkan W & Burnstein KL
ONCOGENE 31, 716-727 (2012)
PubMed | PDF

46.

In Review Ligand Binding and Membrane Insertion Compete with Oligomerization of the BclXL Apoptotic Repressor
Bhat V, McDonald CB, Mikles DC, Deegan BJ, Seldeen KL, Bates ML & Farooq A
J MOL BIOL 416, 57-77 (2012)
PubMed | PDF

45.

In Review Biophysical Analysis of Binding of WW Domains of YAP2 Transcriptional Regulator to PPXY Motifs within WBP1 and WBP2 Adaptors
McDonald CB, McIntosh SKN, Mikles DC, Bhat V, Deegan BJ, Seldeen KL, Saeed AM, Buffa L, Sudol M, Nawaz Z & Farooq A
BIOCHEMISTRY 50, 9616-9627 (2011)
PubMed | PDF

44.

In Review Structural and Thermodynamic Consequences of the Replacement of Zinc with Environmental Metals on ERα-DNA Interactions
Deegan BJ, Bona AM, Bhat V, Mikles DC, McDonald CB, Seldeen KL & Farooq A
J MOL RECOG 24, 1007-1017 (2011)
PubMed | PDF

43.

In Review Energetic Coupling Along an Allosteric Communication Channel Drives the Binding of Jun-Fos Heterodimeric Transcription Factor to DNA
Seldeen KL, Deegan BJ, Bhat V, Mikles DC, McDonald CB & Farooq A
FEBS J 278, 2090-2104 (2011)
PubMed | PDF

42.

In Review S-Nitrosylation of ApoE in Alzheimer's Disease
Abrams AJ, Farooq A & Wang G
BIOCHEMISTRY 50, 3405-3407 (2011)
PubMed | PDF

41.

In Review Binding of the cSH3 Domain of Grb2 Adaptor to Two Distinct RXXK Motifs within Gab1 Docker Employs Differential Mechanisms
McDonald CB, Seldeen KL, Deegan BJ, Bhat V & Farooq A
J MOL RECOG 24, 585-596 (2011)
PubMed | PDF

40.

In Review Whole-Exome Sequencing Links a Variant in DHDDS to Retinitis Pigmentosa
Zuchner S, Dallman J, Wen R, Beecham G, Naj A, Farooq A, Kohli MA, Whitehead PL, Hulme W, Konidari I, Edwards YJ, Cai G, Peter I, Seo D, Buxbaum JD, Haines JL, Blanton S, Young J, Alfonso E, Vance JM, Lam BL & Pericak-Vance MA
AM J HUM GENET 88, 201-206 (2011)
PubMed | PDF

39.

In Review Genetic Variations within the ERE Motif Modulate Plasticity and Energetics of Binding of DNA to the ERα Nuclear Receptor
Deegan BJ, Bhat V, Seldeen KL, McDonald CB & Farooq A
ARCH BIOCHEM BIOPHYS 507, 262-270 (2011)
PubMed | PDF

38.

In Review MASP1 Mutations in Patients with Facial, Umbilical, Coccygeal, and Auditory Findings of Carnevale, Malpuech, OSA, and Michels Syndromes
Sirmaci A, Walsh T, Akay H, Spiliopoulos M, Sakalar YB, Hasanefendioglu-Bayrak A, Duman D, Farooq A, King MC & Tekin M
AM J HUM GENET 87, 679-686 (2010)
PubMed | PDF

37.

Binding of the ERα Nuclear Receptor to DNA Is Coupled to Proton Uptake
Deegan BJ, Seldeen KL, McDonald CB, Bhat V & Farooq A
BIOCHEMISTRY 49, 5978-5988 (2010)
PubMed | PDF

36.

Y65C Missense Mutation in the WW Domain of the Golabi-Ito-Hall Syndrome Protein PQBP1 Affects Its Binding Activity and Deregulates Pre-mRNA Splicing
Tapia VE, Nicolaescu E, McDonald CB, Musi V, Oka T, Inayoshi Y, Satteson AC, Mazack V, Humbert J, Gaffney CJ, Beullens M, Schwartz CE, Landgraf C, Volkmer R, Pastore A, Farooq A, Bollen M & Sudol M
J BIOL CHEM 285, 19391-19401 (2010)
PubMed | PDF

35.

In Review Dissecting the Role of Leucine Zippers in the Binding of bZIP Domains of Jun Transcription Factor to DNA
Seldeen KL, McDonald CB, Deegan BJ, Bhat V & Farooq A
BIOCHEM BIOPHYS RES COMMUN 394, 1030-1035 (2010)
PubMed | PDF

34.

Assembly of the Sos1-Grb2-Gab1 Ternary Signaling Complex Is Under Allosteric Control
McDonald CB, Seldeen KL, Deegan BJ, Bhat V & Farooq A
ARCH BIOCHEM BIOPHYS 494, 216-225 (2010)
PubMed | PDF

33.

Biophysical Characterization Reveals Structural Disorder in the Developmental Transcriptional Regulator LBH
Al-Ali H, Rieger ME, Seldeen KL, Harris TK, Farooq A & Briegel KJ
BIOCHEM BIOPHYS RES COMMUN 391, 1104-1109 (2010)
PubMed | PDF

32.

DNA Plasticity Is a Key Determinant of the Energetics of Binding of Jun-Fos Heterodimeric Transcription Factor to Genetic Variants of TGACGTCA Motif
Seldeen KL, McDonald CB, Deegan BJ, Bhat V & Farooq A
BIOCHEMISTRY 48, 12213-12222 (2009)
PubMed | PDF

31.

SH3 Domains of Grb2 Adaptor Bind to PXΨPXR Motifs within the Sos1 Nucleotide Exchange Factor in a Discriminate Manner
McDonald CB, Seldeen KL, Deegan BJ & Farooq A
BIOCHEMISTRY 48, 4074-4085 (2009)
PubMed | PDF

30.

Single Nucleotide Variants of the TGACTCA Motif Modulate Energetics and Orientation of Binding of the Jun-Fos Heterodimeric Transcription Factor
Seldeen KL, McDonald CB, Deegan BJ & Farooq A
BIOCHEMISTRY 48, 1975-1983 (2009)
PubMed | PDF

29.

Evidence that the bZIP Domains of the Jun Transcription Factor Bind to DNA as Monomers Prior to Folding and Homodimerization
Seldeen KL, McDonald CB, Deegan BJ & Farooq A
ARCH BIOCHEM BIOPHYS 480, 75-84 (2008)
PubMed | PDF

28.

Structural Basis of the Differential Binding of the SH3 Domains of Grb2 Adaptor to the Guanine Nucleotide Exchange Factor Sos1
McDonald CB, Seldeen KL, Deegan BJ & Farooq A
ARCH BIOCHEM BIOPHYS 479, 52-62 (2008)
PubMed | PDF

27.

Thermodynamic Analysis of the Heterodimerization of Leucine Zippers of Jun and Fos Transcription Factors
Seldeen KL, McDonald CB, Deegan BJ & Farooq A
BIOCHEM BIOPHYS RES COMMUN 375, 534-538 (2008)
PubMed | PDF

26.

Grb2 Adaptor Undergoes Conformational Change Upon Dimerization
McDonald CB, Seldeen KL, Deegan BJ, Lewis MS & Farooq A
ARCH BIOCHEM BIOPHYS 475, 25-35 (2008)
PubMed | PDF

25.

Coupling of Folding and DNA-Binding in the bZIP Domains of Jun-Fos Heterodimeric Transcription Factor
Seldeen KL, McDonald CB, Deegan BJ & Farooq A
ARCH BIOCHEM BIOPHYS 473, 48-60 (2008)
PubMed | PDF

24.

Muc4-ErbB2 Complex Formation and Signaling in Polarized CACO-2 Epithelial Cells Indicate That Muc4 Acts as an Unorthodox Ligand for ErbB2
Ramsauer VP, Pino V, Farooq A, Carraway CAC, Salas PJI & Carraway KL
MOL BIOL CELL 17, 2931-2941 (2006)
PubMed | PDF

23.

Structural Insights of the Specificity and Catalysis of a Viral Histone H3 Lysine 27 Methyltransferase
Qian C, Wang X, Manzur K, Sachchidanand, Farooq A, Zeng L, Wang R & Zhou MM
J MOL BIOL 359, 86-96 (2006)
PubMed | PDF

22.

New Insights into the Catalytic Activation of the MAPK Phosphatase PAC-1 Induced by its Substrate MAPK ERK2 Binding
Zhang Q, Muller M, Chen CH, Zeng L, Farooq A & Zhou MM
J MOL BIOL 354, 777-788 (2005)
PubMed | PDF

21.

Structure of the Adaptor Protein p14 Reveals a Profilin-Like Fold With Distinct Function
Qian C, Zhang Q, Wang X, Zeng L, Farooq A & Zhou MM
J MOL BIOL 347, 309-321 (2005)
PubMed | PDF

20.

Resonance Assignments for the Endosomal Adaptor Protein p14
Qian C, Zeng L, Farooq A & Zhou MM
J BIOMOL NMR 30, 367-368 (2004)
PubMed | PDF

19.

Molecular Basis of Distinct Interactions Between Dok1 PTB Domain and Tyrosine-Phosphorylated EGF Receptor
Zhang Y, Yan Z, Farooq A, Liu X, Lu C, Zhou MM & He C
J MOL BIOL 343, 1147-1155 (2004)
PubMed | PDF

18.

Structure of the N-Cadherin Prodomain Reveals a Cadherin Extracellular Domain-Like Fold without Adhesive Characteristics
Koch AW, Farooq A, Shan W, Zeng L, Colman DR & Zhou MM
STRUCTURE 12, 793-805 (2004)
PubMed | PDF

17.

Resonance Assignments for the N-Cadherin Prodomain
Koch AW, Farooq A, Zeng L, Colman DR & Zhou MM
J BIOMOL NMR 28, 87-88 (2004)
PubMed | PDF

16.

Structure and Conserved RNA Binding of the PAZ Domain
Yan KS, Yan S, Farooq A, Han A, Zeng L & Zhou MM
NATURE 426, 468-474 (2003)
PubMed | PDF


15.

Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc
Farooq A, Zeng L, Yan KS, Ravichandran KS & Zhou MM
STRUCTURE 11, 905-913 (2003)
PubMed | PDF | Movie

14.

Resonance Assignments of a Viral SET Domain Histone Lysine Methyltransferase
Manzur KL, Farooq A, Zeng L & Zhou MM
J BIOMOL NMR 26, 279-280 (2003)
PubMed | PDF

13.

Resonance Assignments for the PTB Domain of the Signaling Protein Shc
Farooq A, Zeng L & Zhou MM
J BIOMOL NMR 25, 255-256 (2003)
PubMed | PDF


12.

A Dimeric Viral SET Domain Methyltransferase Specific to Lys27 of Histone H3
Manzur KL, Farooq A, Zeng L, Plotnikova O, Koch AW, Sachchidanand & Zhou MM
NAT STRUCT MOL BIOL 10, 187-196 (2003)
PubMed | PDF

11.

Solution Structure of the MAPK Phosphatase PAC1 Catalytic Domain: Insights into Substrate-Induced Enzymatic Activation of MKP
Farooq A, Plotnikova O, Chaturvedi G, Yan S, Zeng L, Zhang Q & Zhou MM
STRUCTURE 11, 155-164 (2003)
PubMed | PDF | Preview

10.

Resonance Assignments of the Catalytic Domain of Human MAPK Phosphatase PAC1
Chaturvedi G, Farooq A, Zeng L & Zhou MM
J BIOMOL NMR 25, 79-80 (2003)
PubMed | PDF

9.

FRS2 PTB Domain Conformation Regulates Interactions with Divergent Neurotrophic Receptors
Yan KS, Kuti M, Yan S, Mujtaba S, Farooq A, Goldfarb MP & Zhou MM
J BIOL CHEM 277, 17088-17094 (2002)
PubMed | PDF

8.

Structural Basis of Lysine-Acetylated HIV-1 Tat Recognition by PCAF Bromodomain
Mujtaba S, He Y, Zeng L, Farooq A, Carlson JE, Ott M, Verdin E & Zhou MM
MOL CELL 9, 575-586 (2002)
PubMed | PDF | Preview

7.

Solution Structure of ERK2-Binding Domain of MAPK Phosphatase MKP3: Structural Insights into MKP3 Activation by ERK2
Farooq A, Chaturvedi G, Mutjaba S, Plotnikova O, Zeng L, Dhalluin C, Ashton R & Zhou MM
MOL CELL 7, 387-399 (2001)
PubMed | PDF

6.

Resonance Assignments of the ERK2-Binding Domain of MAPK Phosphatase MKP3
Farooq A, Zeng L & Zhou MM
J BIOMOL NMR 19, 195-196 (2001)
PubMed | PDF

5.

PTB Domains of Shc and IRS-1 Recognize the NPXpY Motif in a Thermodynamically Distinct Manner
Farooq A, Plotnikova O, Zeng L & Zhou MM
J BIOL CHEM 274, 6114-6121 (1999)
PubMed | PDF

4.

Kinetic Evidence for an Obligatory Intermediate in the Folding of the Membrane Protein Bacteriorhodopsin
Farooq A
BIOCHEMISTRY 37, 15170-15176 (1998)
PubMed | PDF

3.

Intermediates in the Assembly of Bacteriorhodopsin Investigated by Time-Resolved Absorption Spectroscopy
Booth PJ & Farooq A
FEBS J 246, 674-680 (1997)
PubMed | PDF

2.

Evidence that Bilayer Bending Rigidity Affects Membrane Protein Folding
Booth PJ, Riley ML, Flitsch SL, Templer RH, Farooq A, Curran AR, Chadborn N & Wright P
BIOCHEMISTRY 36, 197-203 (1997)
PubMed | PDF

1.

Retinal Binding During Folding and Assembly of the Membrane Protein Bacteriorhodopsin
Booth PJ, Farooq A & Flitsch SL
BIOCHEMISTRY 35, 5902-5909 (1996)
PubMed | PDF


Copyright © 2004 Farooq Laboratory